Parenthood is a dream for many couples, and infertility can feel like an unexplained mystery.

There are several hidden reasons behind infertility. One of the lesser-known causes is immunological infertility- a condition where your body’s defence system, which is designed to protect you, becomes an unexpected barrier to conception or successful pregnancy.

It is a complex, emotionally challenging condition, and some of the best infertility specialists at the best women’s clinic in Kolkata can help you overcome this challenge with advanced medical aid and increased research.

Let’s see what immunological infertility is-

Immunological infertility occurs when a person’s immune system mistakenly attacks reproductive cells or tissues, treating them as foreign invaders. This can happen in both men and women, and it can interfere with conception, embryo implantation, or sustaining a pregnancy.

 

Know How the Immune System Can Affect Your Fertility-

Usually, the immune system protects the body from infections and diseases. But in some cases, it may:

• Attack sperm cells (in males or the female partner)
• Create antibodies against a partner’s sperm
• React against a fertilised egg or embryo
• Reject the placenta during early pregnancy

This immune overreaction can prevent fertilisation or lead to recurrent miscarriages.

 

What are the types of Immunological Reactions in Infertility?

1. Antisperm Antibodies (ASA):
   This can be found in men or women; these antibodies can kill or immobilise sperm, making fertilisation difficult.
2. Antiphospholipid Syndrome (APS):
   This is a condition where the immune system forms antibodies that increase blood clotting, often linked to repeated miscarriages.
3. Natural Killer (NK) Cells Overactivity:
   High levels of NK cells may attack the embryo before it implants or shortly after.
4. Thyroid Autoimmunity:
   Sometimes, even minor autoimmune thyroid disorders can affect hormonal balance and embryo development.

 

Know the symptoms before it’s too late…

Since there are no obvious physical symptoms of immunological infertility, many couples discover it much later.

Some of the symptoms are,

• Multiple failed IVF attempts

• Recurrent pregnancy loss
• Unexplained infertility despite normal reproductive health

If you experience any of the above, seek advice from the best infertility clinic, where you might have to undergo specialised blood tests to detect antibodies or immune responses that interfere with your pregnancy.

 

Treatment Options that can be available-

Though it is challenging, immunological infertility is manageable with the right approach:

• Steroids or Immunosuppressive Medications – to reduce immune system overactivity
• Intralipid or IVIG Therapy – to balance immune responses
• Heparin and Aspirinare often used in APS to prevent clotting
• Assisted Reproductive Technologies (ART) – like ICSI or IVF with immune support protocols
• Lifestyle and Stress Management – to improve overall immune and hormonal health

Stay Calm. Stay Positive…

Immunological infertility can be emotionally draining, but it is not a dead end. Today, with growing awareness, better diagnostics, and evolving treatment protocols, many couples diagnosed with immune-related infertility have gone on to have healthy pregnancies. The right diagnosis and expert guidance from the infertility specialist can help you overcome this challenge easily.

Understand the signs of your body…

If your body’s defence system gets confused, it can silently sabotage your journey to parenthood.

So, if you suspect your immune system might be the missing link in your fertility journey, immediately consult the infertility specialist of the best women’s clinic in Kolkata.

Remember, in your journey to parenthood, you are not alone…

Keep your hope alive, have faith in science…